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Role of platelet-prostaglandin synthesis in shear-induced platelet alterations.
Exposure of citrated human platelet-rich plasma (C-PRP) to mechanical shear stress has been shown to induce platelet aggregation (PAG), release from platelets of dense granule contents, and platelet lysis. The mechanisms involved in these shear-induced platelet alterations have not been defined. To examine the possible role of prostaglandin (PG) synthesis in shear-induced platelet reactions, C-...
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Introduction: Orexin-A and B (Hypocretin 1 and 2) are neuropeptides that are mostly expressed in the posterior and lateral hypothalamus (LH). Intracisternal (ICV) and intratechal (IT) injections of orexin-A (hypocretin-1) have been shown to elicit analgesic responses in formalin test. However, the locations of central sites that may mediate these effects have not been clearly elucidated. Ore...
متن کاملFor Molecular and Cellular Biology (MCB 1983-06-revised) PAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes
Phosphoprotein associated with glycolipid-enriched membranes (PAG), also named Csk-binding protein (Cbp), is a transmembrane adaptor associated with lipid rafts. It is phosphorylated on multiple tyrosines located in the cytoplasmic domain. One tyrosine, tyrosine 314 (Y314) in the mouse, interacts with Csk, a protein tyrosine kinase (PTK) that negatively regulates Src kinases. This interaction e...
متن کاملPAG-associated FynT regulates calcium signaling and promotes anergy in T lymphocytes.
Phosphoprotein associated with glycolipid-enriched membranes (PAG), also named Csk-binding protein (Cbp), is a transmembrane adaptor associated with lipid rafts. It is phosphorylated on multiple tyrosines located in the cytoplasmic domain. One tyrosine, tyrosine 314 (Y314) in the mouse, interacts with Csk, a protein tyrosine kinase that negatively regulates Src kinases. This interaction enables...
متن کاملFactorization, Inference and Parameter Learning in Discrete Amp Chain Graphs: Addendum
A probability distribution p is Markovian wrt an AMP CG G iff the following three properties hold for all C ∈ Cc(G) (Andersson et al., 2001, Theorem 2): ● C1: C⊥pNdG(C) ∖CcG(PaG(C))∣CcG(PaG(C)). ● C2: p(C ∣CcG(PaG(C))) is Markovian wrt GC . ● C3∗: For all D ⊆ C, D⊥pCcG(PaG(C)) ∖ PaG(D)∣PaG(D). Lemma 1. C1, C2 and C3∗ hold iff the following two properties hold: ● C1∗: For all D ⊆ C, D⊥pNdG(D) ∖ ...
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